Table 1.
Comparison of clinical parameters and biochemical indicators between CRC group and control group [( ± s, n (%)]
| Variable | CRC group (n = 100) |
Pa value | Control group (n = 100) | Pb value | |
|---|---|---|---|---|---|
| Before surgery | After surgery | ||||
| Age (years) | 55.50 ± 8.87 | 55.50 ± 8.87 | NS | 53.31 ± 10.58 | NS |
| Sex | |||||
| Male | 64 (64) | 64 (64) | NS | 36 (36) | NS |
| Female | 53 (53) | 53 (53) | 47 (47) | ||
| Smokers | |||||
| Current | 21 (21) | 21 (21) | NS | 30 (30) | NS |
| Ex | 10 (10) | 10 (10) | NS | 7 (7) | NS |
| Alcohol | 40 (40) | 40 (40) | NS | 33 (33) | NS |
| NSAIDs | 16 (16) | 16 (16) | NS | 10 (10) | NS |
| Diabetes | 6 | 6 | NS | 5 | NS |
| Family history of CRC | 7 (7) | 7 (7) | NS | 1 (1) | 0.030 |
| BMI (kg/m2) | 23.49 ± 2.73 | 23.42 ± 2.66 | NS | 22.81 ± 2.78 | NS |
| WC (cm) | 84.8 ± 8.6 | 84.6 ± 8.7 | NS | 83.5 ± 7.5 | 0.236 |
| WHR | 0.89 ± 0.07 | 0.89 ± 0.09 | NS | 0.87 ± 0.07 | 0.043 |
| SBP (mmHg) | 127 ± 16 | 126 ± 17 | NS | 128 ± 20 | 0.940 |
| DBP (mmHg) | 79 ± 11 | 80 ± 12 | NS | 82 ± 13 | 0.055 |
| TCH (mmol/L) | 4.77 ± 0.92 | 4.79 ± 0.89 | NS | 4.37 ± 0.90 | 0.003 |
| TG (mmol/L) | 1.59 ± 0.95 | 1.57 ± 0.87 | NS | 1.46 ± 0.80 | 0.287 |
| LDL-C (mmol/L) | 2.89 ± 0.97 | 2.88 ± 0.93 | NS | 2.53 ± 0.50 | 0.001 |
| HDL-C (mmol/L) | 1.17 ± 0.49 | 1.16 ± 0.52 | NS | 1.65 ± 0.14 | 0.006 |
| FPG (mmol/L) | 6.17 ± 4.45 | 6.34 ± 4.72 | NS | 5.50 ± 1.16 | NS |
| FABP4 (pg/ml) | 302.24 ± 56.58 | 268.08 ± 33.92 | < 0.001 | 191.97 ± 53.49 | < 0.001 |
| FABP6 (pg/ml) | 411.86 ± 83.25 | 354.64 ± 41.79 | < 0.001 | 289.66 ± 48.57 | < 0.001 |
| CEA (ng/ml) | 8.88 ± 1.26 | 6.72 ± 1.32 | 0.029 | 5.08 ± 0.81 | 0.001 |
| CA-199 (U/ml) | 14.50 ± 3.39 | 12.40 ± 4.36 | 0.048 | 11.02 ± 2.41 | 0.004 |
Abbreviations: NSAID non-steroid anti-inflammatory drug, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, WC waist circumference, WHR waist:hip ratio, TCH total cholesterol, TG triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, FPG fasting plasma glucose, FABP4 fatty acid-binding proteins 4, FABP6 fatty acid-binding proteins 6, CEA carcinoembryonic, CA19-9 carbohydrate antigen 19-9, NS non-significant Intergroup comparisions, Pa after surgery vs before surgery, Pb control group vs CRC group before surgery)