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(A) Secondary structure of pre-miRNA-21 (pre-miR-21; numbers based on miRBASE v21 (Kozomara, & Griffiths-Jones, 2014), the Dicer cleavage sites are indicated by red arrows to generate the ~22 nucleotide mature miR-21 (blue). (B) Structure of pre-miR-21-L50 complex with nucleotides that make intermolecular NOEs highlighted in green (PDB ID: 5UZZ; Shortridge et al, 2017). (C) Both Ile-10 and Arg-12 contact the RNA near one of the Dicer cleavage sites.
