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. Author manuscript; available in PMC: 2020 Jun 13.
Published in final edited form as: Methods Enzymol. 2019 Jun 13;623:339–372. doi: 10.1016/bs.mie.2019.04.029

Figure 8.

Figure 8.

(A) JB-181 (wheat) bound to HIV-TAR (grey) (PDB ID: 6D2U; Shortridge et al, 2018). (B) Overlaid of HIV-TAR-bound structures (grey) for L-22 (magenta) (PDB ID: 2KDQ; Davidson, 2009) and JB-181 (wheat). HIV-TAR backbone phosphates were used as anchor points for the superposition. (C) Dab-1 forms salt bridges with the G21 and A22 phosphates. (D) noR-11 makes a cation-π interaction with A35 favoring a syn conformation for the A35 base. (E) Change in peptide position favors formation of a novel hydrogen bond between Lys-6 and U25 O4.