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In the seizure onset zone (SOZ), the firing rate of inhibitory neurons increases during low-voltage fast (LVF) onset and is followed by an increase in the firing rate of excitatory neurons. Comparison is shown of the mean action potential firing rate after smoothing using a Gaussian kernel for excitatory (blue) and inhibitory (red) neurons before and during LVF onset in the entorhinal cortex, hippocampus, and amygdala SOZ. Shaded areas represent the standard error of the mean.
