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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Osteoarthritis Cartilage. 2019 Jun 29;27(10):1526–1536. doi: 10.1016/j.joca.2019.06.005

Figure 2.

Figure 2.

Low-level cyclic compression attenuated post-traumatic cartilage degradation. (A) Representative Safranin O/Fast Green histological images show that DMM surgery led to focal erosion extending to the tidemark in the medial tibial plateau in the DMM-only group. Loading at 1.0N attenuated DMM-induced cartilage erosion, evident from the intact cartilage surface. Loading at 2.0N had similar effects to 1.0N-loading, with an intact cartilage surface after 6 weeks. Moderate loading at 4.5N resulted in mild erosion and proteoglycan loss that was not different from DMM-only. (B) Average and (C) max OARSI scores for cartilage damage were significantly different between the DMM-only vs. DMM+1.0N groups at +6-weeks. (D) 2.0N-loading also led to lower average OARSI scores than DMM-only, (E) but not lower max OARSI scores. Scale bars =100 μm. Arrows indicate proteoglycan loss; arrow heads indicate erosion. Mean ± SD shown with individual data points overlaid. Different letters between bars indicate significant differences in the means by two-factor ANOVA, followed by Tukey post-hoc tests (p<0.05).