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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Osteoarthritis Cartilage. 2019 Jun 29;27(10):1526–1536. doi: 10.1016/j.joca.2019.06.005

Figure 3.

Figure 3.

Low-level cyclic compression attenuated post-traumatic osteophyte formation. (A) Representative Safranin O/Fast Green histological images indicate that DMM surgery led to osteophyte formation on the anteromedial aspect of the tibial plateau as quickly as 5 days postsurgery. (B) Anteromedial osteophyte size increased in the DMM-only groups after 2 and 6 weeks, but was not different between the DMM+1.0N groups and +0-week DMM-only group (C) Low-level cyclic compression completely suppressed posteromedial osteophyte formation in nearly all animals. (D) Posteromedial osteophyte size in the DMM+1.0N group was lower compared to DMM-only groups. Scale bars =100 pm. Mean ± SD shown with individual data points overlaid. Different letters between bars indicate significant differences in the means by two-factor ANOVA, followed by Tukey post-hoc tests (p<0.05).