Skip to main content
. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Osteoarthritis Cartilage. 2019 Jun 29;27(10):1526–1536. doi: 10.1016/j.joca.2019.06.005

Figure 4.

Figure 4.

Low-level cyclic compression attenuated post-traumatic subchondral bone sclerosis. (A) At the +6-week time point, subchondral bone plate TMD increased in the medial tibial plateau in DMM-only limbs compared to contralateral control limbs. TMD was not different between control and operated limbs in the 1.0N-, 2.0N-, or 4.5N-loaded groups. (B) Mice in the DMM-only group had thicker medial subchondral cortical bone compared to mice in the moderate load group (DMM+4.5N). Mean ± SD shown with individual data points overlaid. Different letters between bars or groups indicate significant differences in the means by two-factor ANOVA, followed by Tukey post-hoc tests (p<0.05). Asterisk on y-axis title indicates significance by post-hoc comparisons for control vs. DMM-operated limbs.