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. Author manuscript; available in PMC: 2019 Oct 25.
Published in final edited form as: ACS Catal. 2019 Apr 22;9:4862–4866. doi: 10.1021/acscatal.9b00851

Scheme 1. Chemoselective Co-Catalyzed Alkylationsa.

Scheme 1.

aIsolated yields shown are of a mixture of 2aq and 2ar. Standard C–P bond formation: 1as (1.0 equiv), Tf2O (1.0 equiv), PPh3 (1.1 equiv), DBU (1.0 equiv) CH2Cl2, −78 °C to rt. Switch C–P bond formation: 1as (1.0 equiv), Tf2O (2.0 equiv), PPh3 (2.0 equiv), NEt3 (2.0 equiv) CH2Cl2, −78 °C to rt. Co-catalysis: 10 mol % Co(acac)3, 10 mol % L3, N-Methylimidazole (1.5 equiv), THF, 50 °C.