Table 3. LE with and without NCD at age 50 among TSH and FT4 tertiles in men and women.
| TSH/FT4 tertiles |
Differences in total LE (95% CI) (p-value) | Differences in LE free of NCD (95% CI) (p-value) | Differences in LE with NCD (95% CI) (p-value) |
|---|---|---|---|
| TSH tertiles† | |||
| Men | |||
| Tertile 1 | Reference | Reference | Reference |
| Tertile 2 | 1.4 (0.5–2.1) (<0.001) | 0.6 (−0.3 to 1.4) (0.1) | 0.8 (−0.1 to 1.8) (0.09) |
| Tertile 3 | 1.5 (0.8–2.3) (<0.001) | 0.1 (−0.8 to 1.2) (0.8) | 1.4 (0.5–2.3) (0.002) |
| Women | |||
| Tertile 1 | Reference | Reference | Reference |
| Tertile 2 | 1.4 (0.6–2.0) (<0.001) | 0.7 (−0.2 to 1.6) (0.1) | 0.7 (−0.2 to 1.5) (0.1) |
| Tertile 3 | 1.5 (0.8–2.2) (<0.001) | 0.2 (−0.8 to 1.3) (0.7) | 1.3 (0.3–2.1) (0.004) |
| FT4 tertiles# | |||
| Men | |||
| Tertile 1 | Reference | Reference | Reference |
| Tertile 2 | −2.0 (−3.4 to −0.7) (0.003) | −1.6 (−2.8 to −0.5) (0.006) | −0.4 (−1.6 to 0.9) (0.5) |
| Tertile 3 | −3.7 (−5.1 to −2.2) (<0.001) | −1.8 (−3.1 to −0.7) (0.003) | −1.9 (−3.4 to −0.3) (0.01) |
| Women | |||
| Tertile 1 | Reference | Reference | Reference |
| Tertile 2 | −1.8 (−3.0 to −0.7) (0.002) | −1.7 (−2.9 to −0.6) (0.003) | −0.1 (−1.1 to 1.2) (0.8) |
| Tertile 3 | −3.3 (−4.7 to −1.9) (<0.001) | −2.0 (−3.4 to −0.7) (0.003) | −1.3 (−2.7 to 0.2) (0.07) |
NCDs include cardiovascular disease, diabetes mellitus, and cancer. Data are given as years (95% CIs). Multistate life tables were used to calculate LE estimates at the age of 50 years, using prevalence, incidence rates and hazard ratios for three transitions (healthy to NCD, healthy to death, and NCD to death). The 95% CI estimates were calculated using Monte Carlo method. The null hypothesis assumes that there are no differences in LE among tertiles of thyroid function measurements. All life expectancies have been calculated with hazard ratios adjusted for age, cohort, smoking, alcohol intake, education level, marital status, body mass index, systolic blood pressure, total cholesterol, triglycerides, use of antihypertensive medications, and use of lipid-lowering medications.
†For this analysis, differences in LE are calculated using the first TSH tertile as reference.
#For this analysis, differences in LE are calculated using the first FT4 tertile as reference.
Abbreviations: CI, confidence interval; FT4, free thyroxine; LE, life expectancy; NCD, noncommunicable disease; TSH, thyroid-stimulating hormone