Figure 1 |. Islet on a Chip design.

a. Illustration of parallel glucose delivery (red lines) and insulin collection (blue lines) from native islets in a human pancreas. b. Overhead drawing of the “Islet on a Chip” with labeled perfusion channels and traps. c. Photograph of fabricated chip with optical micrographs of glucose inlets for islet stimulation (i), traps with a trapped human islet shown in the inset (ii), reagent inlets and mixing motifs (iii), and an integrated glass capillary for detection of optical signals for insulin sensing (iv). Main scale bars denote 1 mm, while scale bar for inset of ii indicates 400 μm.