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. Author manuscript; available in PMC: 2020 Sep 10.
Published in final edited form as: Lab Chip. 2019 Sep 10;19(18):2993–3010. doi: 10.1039/c9lc00253g

Table 1 |.

Design Criteria for Islet on a Chip

Design Criteria Approach
Autoclavable • Polycarbonate
Optically transparent material
Automated islet loading • Hydrodynamic trapping
Sufficient oxygen (3.6 pmol/min*islet) 35 • Oxygenated medium at 1.4 μL/min (24.3 pmol/min*trap) 36
Homogeneous glucose delivery • Flow resistance-matched channels leading to isolated islets
Dynamic glucose delivery • Two inlets for mixing high and low glucose solutions
Continuous on-chip insulin sensing • On-chip competitive binding and detection of fluorescence anisotropy
Detectable insulin output • Low flow rate (1.6 μL/min)
Short lag in glucose delivery and insulin detection • Minimal internal volume