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A. Nav1.8 percent inhibition data distribution and B. select hits. The mean of the Nav1.8 activity distribution was 22.2% inhibition with a right side SD of 33.3. This skewed distribution was from the larger number of hits relative to library size. For this reason we used the left side SD of 17.6 for statistical analysis. This resulted in 2SD and 3SD cutoffs of 57.4% and 75.0% inhibition, respectively. 92 compounds produced >3SD inhibition.
