Date	Event	Description
19 September 2019	New citation required but conclusions have not changed	New searches have been undertaken for this update and minor changes have been made throughout the review.
19 September 2019	New search has been performed	A search of the Cochrane Cystic Fibrosis and Genetic Disorders Group's Haemoglobinopathies Trials Register identified 44 references, 43 references were excluded once duplicates had been removed, 1 was a secondary citation of an excluded study. An additional search was performed that identified 1,282 references plus 292 ongoing trials, which were reduced to 872 references plus 189 ongoing trials once duplicates had been removed, and to 254 references plus 23 ongoing trials once previously screened references had been removed. These were all excluded on the basis of the abstract.