Date	Event	Description
16 May 2016	New citation required but conclusions have not changed	The review was updated according to the new MECIR guidelines. New review authors have produced this updated version of the review which now conforms to the current Cochrane standards.
16 May 2016	New search has been performed	We updated the search of the Cochrane Cystic Fibrosis and Genetic Disorders Group's Haemoglobinopathies Trials Register but no new trials were identified. We expanded and updated additional searches for trials (Appendix 1); however, we did not identify any that were eligible for inclusion. Eight further studies have been added to the 'Excluded studies' section (Atilla 2011; Barst 2010; Chueamuangphan 2014; Detterickh 2015; Lunt 2016; NCT00023296; Styles 2006; Styles 2012).
24 October 2013	New citation required but conclusions have not changed	No new trials have been included in the review update, only minor changes have been made throughout the review.
24 October 2013	New search has been performed	Updated searches did not identify any eligible trials.