Figure 1. Greater effects of inosine on serum and CSF urate in women than men.

(A) Serum urate was measured prior to treatment randomization (baseline), after steady-state dosing of inosine was achieved (2 months visit), and on the last visit on study drug (∼18 months), and values are presented for each of the 3 treatment arms (placebo, and inosine [Ino] dosed to produce a mild or moderate [mod] elevation in serum urate in women and men) (upper panel). Values plotted are point estimates and standard errors from the shared-baseline, repeated-measures, mixed model analysis of variance (ANOVA). (B) CSF urate was measured only once, at the 3-month visit, and is shown for each treatment group, stratified for women and men (upper panel). Values plotted are point estimates and standard errors from the two-way ANOVA.