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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Environ Toxicol Pharmacol. 2019 Sep 12;72:103263. doi: 10.1016/j.etap.2019.103263

Figure 3. Effect of 24 h PCP exposure on synthesis of IL-6 in PBMCs where the p44/42 pathway or p38 pathway are inhibited.

Figure 3.

Effects of the inhibition of selected signaling pathways on the production of IL-6 from human PBMCs after 24 h exposures to PCP. A) MEK inhibitor (PD98059). Data is from a 2 experiments (F570 and F571). Data from additional experiments are given in Table 3; B) p38 inhibitor (SB202190). Data is from a representative experiment (F570). Data from additional experiments are given in Table 3. An increase in secretion or in intracellular level is a number greater than 1 a decrease in secretion or intracellular level is a number less than 1. The control is arbitrarily set at 1. Cells treated with inhibitor are compared to control cells treated with inhibitor. A combined fold increase (secretion + intracellular) greater than 1 indicates an increase in production.

NI indicates no significant increase in production (fold increase ≤1); NS indicates no significant change in secretion (p>0.05)