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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Environ Toxicol Pharmacol. 2019 Sep 12;72:103263. doi: 10.1016/j.etap.2019.103263

Figure 6. Effect of 6 h DDT exposure on synthesis of IL-6 in PBMCs where the p44/42 pathway or p38 pathway are inhibited.

Figure 6.

Effects of the inhibition of selected signaling pathways on the production of IL-6 from human PBMCs after 6 h exposures to DDT. A) MEK inhibitor (PD98059). Data is from a representative experiment (F590). Data from additional experiments are given in Table 6; B) p38 inhibitor (SB202190). Data is from a representative experiment (F593). Data from additional experiments are given in Table 3. An increase in secretion or in intracellular level is a number greater than 1 a decrease in secretion or intracellular level is a number less than 1. The control is arbitrarily set at 1. Cells treated with inhibitor are compared to control cells treated with inhibitor.

NI indicates no significant increase in production (fold increase ≤1); NS indicates no significant change in secretion (p>0.05)