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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Environ Toxicol Pharmacol. 2019 Sep 12;72:103263. doi: 10.1016/j.etap.2019.103263

Table 2:

Effects of 2 h, 6 h, and 24 h exposures to PCP on IL-6 mRNA levels in PBMCs

2h Interleukin 6 mRNA expression (AU) (mean± S.D.)
[PCP]
µM
F563 F564 F565 F566
0 46±3 64±6 30±3 18±0.5
0.05 24±1* 64±6 32±2 29±1+
0.1 30±2* 73±2 35±3 28±2+
0.25 27±0.7* 65±3 30±2 23±0.6+
0.5 32±1* 72±0.4 26±1 25±1+
1 28±6* 66±1 26±1 22±1+
2.5 25±0.2* 75±16 18±2* 22±1+
5 17±2* 41±3* 14±1* 17±0.6
6h Interleukin 6 mRNA expression (AU) (mean± S.D.)
[PCP]
µM
F538 F540 F541 F542
0 23±0.5 11±7 8±0.6 23±1
0.05 19±0.3* 14±3 45±8+ 18±0.8*
0.1 25±0.4+ 18±3 27±13 15±0.4*
0.25 19±0.3* 11±0.8 28±3+ 18±0.6*
0.5 24±0.2+ 17±2 28±11 16±0.5*
1 15±1* 16±0.4 36±19 31±2+
2.5 12±0.1* 22±1 30±8+ 43±11
5 18±0.3* 12±4 21±2+ 55±18
24h Interleukin 6 mRNA expression (AU) (mean± S.D.)
[PCP]
µM
F525 F527 F528 F530 F548
0 27±2 15±0.1 5±1 13±1 9±2
0.05 21±2* 14±1 19±1+ 13±1 11±1
0.1 31±1+ 15±2 14±3+ 10±1* 16±2+
0.25 39±4+ 16±0.4+ 11±1+ 13±1 15±1+
0.5 43±3+ 19±.1+ 16±3+ 10±0.4* 10±1
1 37±1+ 17±1 14±3+ 7±0.2* 8±.4
2.5 30±1 14±1 22±2+ 9±3 9±1
5 25±8 11±1* 19±3+ 9±0.3 5±1*

Values are mean±S.D. of triplicate determinations.

*

Indicates a significant decrease in secretion and

+

indicates a significant increase in secretion compared to control cells (cells treated with vehicle alone), p<0.05