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Changes in cellular metabolism of senescent T cells. In activated senescent T cells, ATP production is impaired due to altered glycolytic flux and compromised mitochondrial respiration. Though old T cells have higher mtROS leakage, enhanced pentose phosphate pathway results in a burst of reductive molecule and clearance of mtROS. NFAT and NF-κB fail to translocate into nuclear because of altered cellular redox state. Consequently, the production of IL-2 is impaired.
