Table 3. Aggregation of native and estradiol pre-treated platelets after ADP or PAF stimulation by sex.

Data presented as median (25–75 interquartile range). P value reflective of Wilcoxon signed rank test.

Stimulant ± Estradiol	ESC (%)
	ADP (Untreated)	ADP (Estradiol)	p value	PAF (Untreated)	PAF (Estradiol)	p value
By Sex
Females (n=9)	35.6 (34.9−39.6)	34.7 (32.6−40.8)	0.30	37.0 (30.6−40.3)	37.6 (28.6−42.4)	0.82
Males (n=12)	35.8 (32.7−39.4)	34.9 (30.6−37.8)	0.42	34.0 (29.9−40.2)	33.5 (28.0−38.2)	0.13
By Sex and Age
Premenopausal females (n=4)	35.6 (31.4−38.8)	35.0 (30.8−38.6)	0.12	33.2 (28.2−37.0)	32.8 (22.8−38.5)	0.89
Postmenopausal females (n=5)	35.9 (34.9−40.0)	33.7 (32.6−42.4)	0.62	39.6 (35.2−41.6)	41.1 (33.4−44.7)	0.31
Young males (n=6)	35.0 (31.0−39.4)	34.0 (29.9−36.2)	0.44	31.2 (30.2−40.8)	31.7 (29.0−37.8)	0.16
Older males (n=6)	37.0 (30.8−40.1)	37.2 (28.8−39.2)	0.84	37.2 (23.2−40.0)	36.4 (22.5−38.6)	0.56

ADP=adenosine diphosphate, PAF=platelet activating factor, ESC=extent shape change