Table 4. Activation, as assessed by CD41 receptor surface expression, in native and estradiol-incubated platelets after ADP or PAF stimulation by sex.
Data presented as median (25–75 interquartile range). P value reflective of Wilcoxon signed rank test.
| CD41 Receptor Surface Expression (MFI) | ||||||
|---|---|---|---|---|---|---|
| Stimulant ± Estradiol | ADP (Untreated) | ADP (Estradiol) | p value | PAF (Untreated) | PAF (Estradiol) | p value |
| By Sex | ||||||
| Females (n=9) | 3860 (2842−5385) | 3533 (2422−4682) | 0.25 | 3231 (1832−4430) | 4581 (3455−6447) | 0.004 |
| Males (n=12) | 3623 (2074−4571) | 2469 (1828−4185) | 0.52 | 2490 (1391−4921) | 3872 (2195−5691) | 0.009 |
| By Sex and Age | ||||||
| Premenopausal females (n=4) | 4585 (3392−5435) | 3946 (3243−4615) | 0.25 | 2355 (1266−4251) | 4959 (3110−6784) | 0.12 |
| Postmenopausal females (n=5) | 3644 (1866−5267) | 2786 (1712−5163) | 0.81 | 3452 (2472−5531) | 4581 (3111−6080) | 0.06 |
| Young males (n=6) | 3870 (1848−4882) | 2088 (1680−5147) | 0.99 | 2490 (1233−5863) | 4544 (3322−6320) | 0.03 |
| Older males (n=6) | 3203 (1949−4536) | 2977 (1870−3985) | 0.44 | 2434 (1635−4349) | 2443 (2038−5434) | 0.31 |
ADP=adenosine diphosphate, PAF=platelet activating factor