A-F. Changes in body weight (A), lean body mass (B), body fat mass (C), glycemia (D), oxygen consumption (VO2, E) and respiratory exchange ratio (RER, F) in control (n = 8) and POMC GHR KO (n = 8) male mice subjected to 5 days of 60% food restriction. G-J. Changes in body weight (A), lean body mass (B), body fat mass (C) and glycemia (D) in control (n = 7) and POMC GHR KO (n = 8) female mice subjected to 5 days of 60% food restriction. The data were analyzed by repeated measures two-way ANOVA. *, P < 0.05 (Bonferroni’s multiple comparisons test).