A-G. Body weight (A), lean body mass (B), body fat mass (C), daily food intake (D), oxygen consumption (VO2; E), ambulatory activity (F) and serum leptin levels (G) of control (n = 8-14) and POMC STAT5 KO (n = 9-25) male mice. H-N. Body weight (H), lean body mass (I), body fat mass (J), daily food intake (K), VO2 (L), ambulatory activity (M) and serum leptin levels (N) of control (n = 10-26) and POMC STAT5 KO (n = 10-15) female mice. Body weight changes were analyzed by repeated measures two-way ANOVA and the remaining comparisons between groups were performed using two-tailed Student’s t-test. *, P < 0.05 comparing control and POMC STAT5 KO mice (two-tailed Student’s t-test).