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. 2019 Oct 10;11(19):8374–8385. doi: 10.18632/aging.102325

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Copyright © 2019 Fu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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MBTD1 is highly expressed in osteosarcoma and associated with poor prognosis, and MBTD1 promotes cell viability and inhibits apoptosis. (A, B) The expression level of MBTD1 in osteosarcoma tissues and adjacent tissues is shown. © 5-year survival analysis of osteosarcoma patients with different MBTD1 levels is shown. (D–H) The effects of MBTD1 knockdown or overexpression on MBTD1 protein expression levels are shown. (I–L) The effect of knockdown or overexpression of MBTD1 on cell viability and apoptosis is shown. ^*P < 0.05 vs. normal tissue or sh-NC group; ^#P < 0.05 vs. vector-NC.