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. 2019 Oct 11;11(19):8664–8680. doi: 10.18632/aging.102354

Figure 8.

Figure 8

c-Jun N-terminal kinase (JNK) and nuclear factor-κB (NF-κB) are involved in RIPK1-mediated inflammation. (A, B) Expression levels of p-JNK, p-IKBα, and p-P65 in chondrocytes. The experiments were repeated three times independently. Columns represent means ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. © Schematic of the TIR-domain-containing adapter-inducing interferon b (TRIF)/MYD88-RIPK1-tumor necrosis factor receptor-associated factor 2 (TRAF2) feedback loop and activation of the NF-κB and JNK signaling pathways in OA.