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. 2019 Oct 3;11(19):8386–8417. doi: 10.18632/aging.102326

Table 2. Top 10 enriched BP terms of up-regulated and down-regulated DEGs.

ID Term DEG(s) p-value FDR Enrichment
Up-regulated
GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway Adamts3, Ccbe1 1.503E-05 0.0040579 294.52778
GO:0006882 cellular zinc ion homeostasis Slc30a1, Mt2 0.0003851 0.0406079 67.967949
GO:0006829 zinc ion transport Slc30a1, Slc30a10 0.0015749 0.0406079 33.983974
GO:0006730 one-carbon metabolic process Mat2a, Mthfr 0.0020959 0.0406079 29.452778
GO:0035212 cell competition in a multicellular organism Vprbp 0.0022635 0.0406079 441.79167
GO:0090230 regulation of centromere complex assembly H3f3b 0.0022635 0.0406079 441.79167
GO:0030575 nuclear body organization Neat1 0.0022635 0.0406079 441.79167
GO:1990245 histone H2A-T120 phosphorylation Vprbp 0.0022635 0.0406079 441.79167
GO:0036018 cellular response to erythropoietin Mt2 0.0022635 0.0406079 441.79167
GO:0071584 negative regulation of zinc ion transmembrane import Slc30a1 0.0022635 0.0406079 441.79167
Down-regulated
GO:0034765 regulation of ion transmembrane transport Cacng2, Kcnh3, Kcna3, Kcnj4, Cacna1i, Kcnc4, Kcnab3, Kcnj11, Scn1b, Kcnj9, Kcnf1, Kcnb1, Cacng7, Kcnk3, Kcnc1, Kcnj2 6.587E-10 8.642E-07 7.3469317
GO:0071805 potassium ion transmembrane transport Kcnh3, Kcna3, Kcnk12, Kcnj4, Kcnc4, Kcnab3, Kcnj11, Kcnf1, Kcnb1, Kcnk3, Kcnc1, Kcnj2 6.591E-08 3.715E-05 7.5871199
GO:0006813 potassium ion transport Kcnh3, Kcna3, Kcnj4, Kcnc4, Kcnab3, Kcnj11, Kcnj9, Kcnf1, Kcnb1, Kcnk3, Kcnc1, Kcnj2 8.495E-08 3.715E-05 7.4159818
GO:0000122 negative regulation of transcription from RNA polymerase II promoter Scrt1, Fgfr3, Mxi1, Egr1, Pou3f3, Zbtb16, Nfix, Bcl6, Nr2f1, Klf5, Tbx3, Eng, Xbp1, Fezf2, Satb2, Calr, Dab2ip, Ppard, Foxg1, Sox18, Hivep1, Dusp26, Klf4, Cry1 4.431E-06 0.0014534 2.850652
GO:0007399 nervous system development Igsf9, Ina, Pou3f3, Sema7a, Nes, Nr2f1, Lmtk2, Fezf2, Cit, Ndel1, Brsk1, Nrsn1, Gdpd5, Sema6c, Bax, Pten 8.858E-06 0.0023242 3.6734659
GO:0018105 peptidyl-serine phosphorylation Ulk1, Adrbk1, Pink1, Lmtk2, Brsk1, Ttbk1, Csnk1e, Sbk1 1.945E-05 0.0041297 6.9952169
GO:0006811 ion transport Cacng2, Kcnh3, Kcna3, Slc38a2, Kcnk12, Kcnj4, Cacna1i, Lasp1, Kcnc4, Fxyd7, Kcnab3, Kcnj11, Grid1, Scn1b, Kcnj9, Kcnf1, Kcnb1, Cacng7, Kcnk3, Kcnc1, Kcnj2 2.203E-05 0.0041297 2.8111885
GO:0006887 exocytosis Stxbp1, Doc2a, Cdk16, Stx1a, Rims3, Srcin1, Rims4, Cplx1 3.524E-05 0.0057795 6.4465724
GO:0007416 synapse assembly Plxnd1, Farp1, Shank2, Clstn3, Pten 4.606E-05 0.0067145 12.453606
GO:0016310 phosphorylation Camk2n2, Prkar1b, Fgfr3, Ulk1, Limk1, Adrbk1, Cdk16, Pink1, Lmtk2, Stk32c, Nlk, Cit, Brsk1, Pik3cd, Ttbk1, Pak6, Camkk2, Tnk2, Mast2, Csnk1e, Sbk1, Cerk 5.219E-05 0.0068479 2.575874

BP: biological process; DEG: differentially expressed gene; FDR: false discovery rate.