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. 2019 Oct 3;11(19):8386–8417. doi: 10.18632/aging.102326

Table 3. Signaling pathway enrichment of up-regulated and down-regulated DEGs.

ID Term DEG(s) p-value FDR Enrichment
Up-regulated
PATH:04978 Mineral absorption Slc30a1, Mt2 0.0037153 0.1263212 21.611594
PATH:03320 PPAR signaling pathway Dbi, Fabp7 0.0111679 0.1898536 12.273251
PATH:00670 One carbon pool by folate Mthfr 0.0375845 0.3333577 26.161404
Down-regulated
PATH:04921 Oxytocin signaling pathway Cacng2, Adcy1, Kcnj4, Kcnj9, Adcy8, Pik3cd, Elk1, Adcy4, Camkk2, Cacng7, Nos3, Kcnj2 2.428E-07 3.569E-05 6.5089481
PATH:04141 Protein processing in endoplasmic reticulum Ubqln4, Hspa5, Hyou1, Syvn1, Xbp1, Calr, Pdia4, Fbxo2, Pdia6, Bax, Man1c1 2.924E-06 0.0002149 5.71341
PATH:04724 Glutamatergic synapse Slc38a2, Grm4, Adcy1, Grm2, Adrbk1, Glul, Adcy8, Adcy4, Shank2 1.52E-05 0.000745 6.0733098
PATH:04915 Estrogen signaling pathway Adcy1, Kcnj9, Adcy8, Pik3cd, Fkbp4, Adcy4, Nos3 0.0001353 0.0049722 6.1215107
PATH:04971 Gastric acid secretion Adcy1, Sst, Adcy8, Cckbr, Adcy4, Kcnj2 0.0002082 0.0061217 6.9487418
PATH:04261 Adrenergic signaling in cardiomyocytes Cacng2, Adrb1, Adcy1, Scn1b, Adcy8, Pik3cd, Adcy4, Cacng7 0.0003244 0.0079469 4.601404
PATH:05414 Dilated cardiomyopathy Cacng2, Adrb1, Adcy1, Adcy8, Adcy4, Cacng7 0.0005682 0.0119312 5.7776056
PATH:05020 Prion diseases Egr1, Hspa5, Elk1, Bax 0.0006871 0.0126259 9.7944171
PATH:04918 Thyroid hormone synthesis Adcy1, Hspa5, Adcy8, Pdia4, Adcy4 0.0013702 0.0223796 6.0352922
PATH:04725 Cholinergic synapse Adcy1, Kcnj4, Adcy8, Pik3cd, Adcy4, Kcnj2 0.0018898 0.0277797 4.591133

DEG: differentially expressed gene; FDR: false discovery rate.