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Multivalent inhibitors of AB5 bacterial toxins. a A schematic representation of polymeric preordered heterobifunctional ligands. b Conceptual design of pentavalent inhibitors based on symmetrical core, variable number of linker units, and monovalent fingers blocking the toxin receptor binding site. Reprinted with permission from Kitov et al. (2008) and Merritt et al. (2002). © 2008 National Academy of Sciences, USA. © 2002 American Chemical Society
