Fig. 6.

Experiments in 14 weeks old Xpg^−/− NER model recapitulate the data obtained in Ercc1^Δ/− mice. a Reduction in transcription levels in vivo measured by EU incorporation. EU was injected in WT and Xpg^−/− mice 14- week old (n = 3 per group). Horizontal bars in the scatter dot plots represent the average fluorescence intensity, n ≥ 200 cells from 3 mice per group. b–d Increased ATP levels paralleled by reduced PFK and increased G6PDH activity. n ≥ 4 per group. e–g Reduced redox state in Xpg^−/− mice as indicated by the GSSG/GSH and thiol/disulfide redox couples. n = 3 per group. Error bars indicate mean ± s.e.m. *p < 0.05, **p < 0.01, ***p < 0.001. Student’s t-test. Original data are provided as Source Data file