Table 2.
Echocardiographic parameters of C57BL/6J and db/db mice.
| 6 weeks old | 20 weeks old | |||
|---|---|---|---|---|
| C57BL/6J | db/db | C57BL/6J | db/db | |
| Anterior wall at end diastole, mm | 0.80 ± 0.02 | 0.96 ± 0.03* | 0.90 ± 0.04* | 1.14 ± 0.03*†# |
| Anterior wall at end systole, mm | 1.31 ± 0.04 | 1.54 ± 0.05* | 1.26 ± 0.05† | 1.63 ± 0.05*# |
| Posterior wall at end diastole, mm | 0.80 ± 0.03 | 0.91 ± 0.04* | 0.88 ± 0.03 | 1.16 ± 0.05*†# |
| Posterior wall at end systole, mm | 1.18 ± 0.05 | 1.32 ± 0.04* | 1.19 ± 0.05 | 1.46 ± 0.06*# |
| LV internal diameter at end diastole, cm | 3.80 ± 0.08 | 3.71 ± 0.13 | 4.17 ± 0.09*† | 3.78 ± 0.16 |
| LV internal diameter at end systole, mm | 2.25 ± 0.12 | 2.08 ± 0.14 | 2.88 ± 0.11*† | 2.58 ± 0.11† |
| Fractional shortening, % | 41 ± 3 | 45 ± 3 | 31 ± 1*† | 31 ± 2*† |
| Peak E wave velocity, mm/s | 682 ± 24 | 746 ± 29 | 573 ± 15*† | 592 ± 28*† |
| Peak A wave velocity, mm/s | 438 ± 22 | 499 ± 15* | 351 ± 21*† | 601 ± 38*†# |
| Peak E/A ratio | 1.59 ± 0.09 | 1.50 ± 0.06 | 1.68 ± 0.08 | 1.00 ± 0.03*†# |
LV = left ventricle; ms = millisecond. *P < 0.05 versus 6 week-old C57BL/6J mice; †P < 0.05 versus 6 week-old db/db mice; and #P < 0.05 versus 20 week-old C57BL/6J mice (n = 12–13 mice/group).