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. 2019 Oct 25;9:15286. doi: 10.1038/s41598-019-51258-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Probability of developing breast cancer or hypothyroidism given a specific polygenic score - shown in SD units and percentile. The lifetime population prevalence of both breast cancer and hypothyroidism are set to be 12%. Deviation from the red line, particularly at large and small PGS percentile, is likely an artifact of low statistics in these regions.