Table 2.

Table of genetic AUCs using SNPs only - no age or sex.

Condition	Training Set	Test Set	AUC	Active SNPs	λ*
Hypothyroidism	impute	UKBB	0.705 (0.009)	3704 (41)	1.406e-06 (1.33e-7)
Hypothyroidism	impute	eMERGE	0.630 (0.006)
Type 2 Diabetes	impute	UKBB	0.640 (0.015)	4168 (61)	6.93e-06 (1.73e-6)
Type 2 Diabetes	impute	eMERGE	0.633 (0.006)
Hypertension	impute	UKBB	0.667 (0.012)	9674 (55)	4.46e-6 (4.86e-7)
Hypertension	impute	eMERGE	0.651 (0.007)
Resistant Hypertension	impute	eMERGE	0.6861 (0.001)
Asthma	calls	AA	0.632 (0.006)	3215 (16)	2.37e-6 (0.35e-6)
Type 1 Diabetes	calls	AA	0.647 (0.006)	50 (7)	7.9e-7 (0.1e-7)
Breast Cancer	calls	AA	0.582 (0.006)	480 (62)	3.38e-6 (0.05e-6)
Prostate Cancer	calls	AA	0.6399 (0.0077)	448 (347)	3.07e-6 (0.08e-8)
Testicular Cancer	calls	AA	0.65 (0.02)	19 (7)	1.42e-6 (0.04e-6)
Glaucoma	calls	AA	0.606 (0.006)	610 (114)	8.69e-7 (0.71e-7)
Gout	calls	AA	0.682 (0.007)	1010 (35)	9.41e-7 (0.03e-7)
Atrial Fibrillation	calls	AA	0.643 (0.006)	181 (39)	8.61e-7 (0.94e-7)
Gallstones	calls	AA	0.625 (0.006)	981 (163)	1.01e-7 (0.02e-7))
Heart Attack	calls	AA	0.591 (0.006)	1364 (49)	1.181e-6 (0.002e-7)
High Cholesterol	calls	AA	0.628 (0.006)	3543 (36)	2.4e-6 (0.2e-6)
Malignant Melanoma	calls	AA	0.580 (0.006)	26 (15)	9.5e-7 (0.8e-7)
Basal Cell Carcinoma	calls	AA	0.631 (0.006)	76 (22)	9.9e-7 (0.3e-7)

Training and validating is done using UKBB data from either direct calls or imputed data to match eMERGE. Testing is done with UKBB, eMERGE, or AA as described in Secs. 2 and Supplementary Information Sec. D. Numbers in parenthesis are the larger of either a standard deviation from central value or numerical precision as described in Sec. 2. λ* refers to the lasso λ value used to compute AUC as described in Sec. 2.