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. 2019 Oct 25;9:15302. doi: 10.1038/s41598-019-51636-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SOCS1 reporter expression is increased during CD8⁺ CTL differentiation in NOD islets. (A) Pancreatic lymph nodes and islets were isolated 5 days after 8.3 splenocyte transfer, CFSE positive cells were isolated by cell sorting and CTL activity quantified in vitro. Data show mean + SEM from 3 independent experiments. **p < 0.01. (B) Representative plots of pancreatic lymph nodes (PLN) and islets isolated 5 days after 8.3/hCD4 splenocyte transfer showing expression of hCD4 and CFSE dilution. (C) Expression of hCD4 (mean fluorescence intensity, MFI) on CD8⁺CFSE⁺ T cells for each cell division was calculated using CFSE dilution profiles. Data show mean ± SEM for n = 6 mice from 3 independent experiments. **p < 0.01, one-way ANOVA comparing division 1 and division 7.