Table 2.
Paired sample t-test comparing pre-empagliflozin and post-empagliflozin variables.
| CMRI parameters | Pre-empagliflozin | Post-empagliflozin | Paired difference | 95% confidence of the difference | p-Value | ||
|---|---|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | Mean | SD | Lower | Upper | ||
| Intracardiac TG (%) |
0.478 ± 0.340 (0.013–1.690) |
0.480 ± 0.246 (0.210–1.110) |
0.002 | 0.418 | −0.148 | 0.153 | 0.973 |
| Pericardial fat (g) |
32.26 ± 14.60 (5.74–82.76) |
27.68 ± 11.12 (12.89–63.34) |
4.576 | 16.432 | −1.069 | 10.221 | 0.109 |
| ECV (%) |
27.4 ± 4.08 (22.42–42.65) |
27.1 ± 2.89 (19.90–37.42) |
0.299 | 4.439 | −1.225 | 1.824 | 0.692 |
| LVEDV (mL) |
94.38 ± 28.21 (41.00–162.00) |
95.00 ± 24.66 (50.33–140.8) |
−0.614 | 17.795 | −6.727 | 5.499 | 0.839 |
| LVESV (mL) |
24.54 ± 19.56 (2.54–79.86) |
25.43 ± 17.11 (4.30–77.55) |
−0.820 | 12.424 | −5.164 | 3.372 | 0.672 |
| nLVEDV (mL/m2) |
53.46 ± 16.20 (25.56–100.11) |
57.80 ± 18.60 (34.95–129.91) |
−4.344 | 19.769 | −11.135 | 2.447 | 0.202 |
| nLVESV (mL/m2) |
13.81 ± 11.94 (1.57–56.78) |
15.17 ± 10.77 (4.60–49.23) |
−1.354 | 6.169 | −3.473 | 0.765 | 0.203 |
| LVEF (%) |
77.23 ± 12.12 (43.28–93.86) |
75.19 ± 11.20 (41.48–91.46) |
2.035 | 6.610 | −0.235 | 4.306 | 0.077 |
| LVPER (ESV/s) |
−3.74 ± 1.01 (−5.62 to −1.41) |
−3.72 ± 1.24 (−5.93 to −2.31) |
−0.015 | 0.841 | −0.304 | 0.274 | 0.919 |
| LVPFR (EDV/s) |
3.87 ± 1.55 (0.57–6.38) |
3.73 ± 1.24 (1.91–6.17) |
0.136 | 1.064 | −0.229 | 0.502 | 0.454 |
| LVMi (g/m2) |
95.11 ± 28.26 (35.39–151.23) |
91.81 ± 26.67 (46.52–135.26) |
3.302 | 13.932 | −1.484 | 8.088 | 0.170 |
| Others | |||||||
| BW (kg) |
70.4 ± 14.5 (49.0–107.0) |
69.9 ± 15.0 (49.0–110.0) |
0.647 | 1.631 | 0.078 | 1.216 | 0.109 |
| SBP (mmHg) |
132.3 ± 17.4 (88–162) |
125.9 ± 15.1 (95–162) |
6.371 | 14.390 | 1.428 | 11.314 | 0.013 |
| DBP (mmHg) |
75.5 ± 12.6 (44–109) |
75.2 ± 9.3 (56–99) |
0.371 | 11.188 | −3.472 | 4.325 | 0.845 |
| Haematocrit (%) |
41.8 ± 4.5 (30.3–54.5) |
43.1 ± 4.2 (35.8–53.8) |
1.400 | 2.200 | 0.600 | 2.200 | 0.001 |
| NT-pro-BNP (pg/mL) |
64.32 ± 66.58 (8.84–283.30) |
67.62 ± 71.33 (7.35–379.80) |
0.691 | 51.583 | −18.230 | 19.612 | 0.942 |
| Creatinine (mg/dL) |
0.9 ± 0.3 (0.5–1.6) |
0.9 ± 0.3 (0.6–1.7) |
−0.147 | 0.089 | −0.046 | 0.016 | 0.343 |
| eGFR (mL/min/1.73 m2) |
82.3 ± 19.4 (46.3–132.9) |
80.1 ± 18.5 (41.6–116.0) |
2.156 | 10.362 | −1.460 | 5.771 | 0.234 |
| HbA1c (%) |
7.0 ± 1.1 (5.3–11.7) |
6.8 ± 0.6 (5.8–8.3) |
0.200 | 0.903 | −0.220 | 0.520 | 0.199 |
| T-CHO (mg/dL) |
167.5 ± 39.3 (68.0–237.0) |
160.0 ± 28.7 (105.0–239.0) |
11.554 | 47.595 | −7.670 | 30.778 | 0.227 |
| TG (mg/dL) |
160.1 ± 94.1 (51.0–401.0) |
144.9 ± 70.4 (44.0–310.0) |
18.889 | 82.167 | −13.615 | 51.393 | 0.243 |
| LDL (mg/dL) |
88.1 ± 22.5 (48.0–144.0) |
81.2 ± 19.9 (49.0–144.0) |
7.130 | 29.910 | −3.842 | 18.100 | 0.194 |
| HDL (mg/dL) |
50.3 ± 11.8 (28.0–77.0) |
52.5 ± 12.9 (27.0–83.0) |
−2.115 | 5.701 | −4.418 | 0.187 | 0.070 |