. 2019 Oct 25;9:15346. doi: 10.1038/s41598-019-51629-4

Table 1.

Patient Demographics and Clinical Characteristics.

Variable	No. of Patients	Local Control		Distant Control		Overall Survival		Disease-free Survival
Variable	No. of Patients	5 years	P-value	5 years	P-value	5 years	P-value	5 years	P-value
Total No. of Patients	411	81.4	—	68.4	—	75.6	—	61.1	—
Clinical diagnosis
Sex			0.272		0.830		0.188		0.657
Male	301	81.6		68.5		73.9		60.7
Female	110	78.1		68.2		80.5		62.2
Age, years			0.253		0.479		0.659		0.909
≤49	141	78.7		69.5		73.2		60.6
50–59	124	82.0		69.0		76.7		63.2
60–69	110	82.3		69.5		81.2		59.2
≥70	36	87.1		60.8		68.6		60.8
cT stage			<0.001^a		0.684		0.002^a		0.120
2	14	92.9		72.2		73.5		66.7
3	301	84.2		69.4		79.0		63.4
4	76	64.6		57.6		63.4		44.6
missing	20
cN stage			0.015^a		0.013^a		0.004^a		0.002^a
0	45	97.7		83.7		100.0		83.7
1–2	326	78.1		66.1		72.4		57.3
missing	40
Treatments
RT dose, Gy			0.193		0.042^a		0.012^a		0.011^a
<50	85	75.1		56.8		61.4		47.6
≥50	326	83.4		72.0		80.5		65.0
Concurrent chemotherapy		0.246		0.909		0.603		0.623
No	9	100.0		71.1		100.0		71.1
Yes	402	81.0		68.3		75.1		60.9
Surgical procedure			0.155		0.280		0.009^a		0.152
LAR	178	81.7		65.8		77.1		59.5
APR	216	82.9		71.7		76.9		63.6
Hartmann	16	66.3		61.9		50.6		55.6
missing	1
Adjuvant chemotherapy		0.410		0.879		0.108		0.635
No	39	81.4		70.1		71.6		56.5
Yes	350	80.9		68.2		77.1		61.5
missing	22
Pathology
pT stage			0.045^a		0.004^a		<0.001^a		<0.001^a
0	88	91.3		79.2		83.9		78.0
1–2	122	82.9		74.5		89.0		65.9
3	171	77.4		58.5		64.9		50.7
4	30	64.3		70.4		54.3		47.3
pN stage			0.002^a		<0.001^a		<0.001^a		<0.001^a
0	248	87.9		79.3		85.6		73.8
1–2	163	69.3		51.0		59.2		40.9
pCR			0.041^a		0.062		0.205		0.007
No	323	79.2		0.658		73.0		56.8
Yes	88	91.4		0.798		87.2		79.9

NOTE. Significant differences between the stratified Kaplan-Meier curves are indicated by the P-value. Five years event values given as percentage.

Abbreviations: APR, abdominoperineal resection; cT stage, clinical tumor stage; cN, clinical nodal stage; LAR, low anterior resection; RT, radiotherapy; pT, pathologic tumor stage; pN, pathologic nodal stage. pCR, pathologic complete response.

^aSignificant overall difference: P < 0.05.