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. 2019 Oct 25;9:15362. doi: 10.1038/s41598-019-51724-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NT3 overexpression reduced noise-induced synaptopathy (a), while GFP overexpression increased synaptopathy with or without noise (b). (a) Summary of synaptic survival for AAV-NT3 groups and relevant controls. Group sizes were as follows: Controls (n = 4), Noise Only (n = 7), Vehicle then Noise (n = 4), Anc80-NT3₂₅₀ Only (n = 4), Anc80-NT3₂₅₀ then Noise (n = 7), Anc80-NT3₁₀₀₀ then Noise (n = 7) and Noise then Anc80-NT3₁₀₀₀ (n = 5). (b) Summary of synapse survival for AAV-GFP groups and relevant controls. Control, Noise Only and Vehicle then Noise groups are the same as in Panel a. Group sizes for the GFP groups were as follows: Anc80-GFP₂₅₀ Only (n = 4), and Anc80-GFP₂₅₀ then Noise (n = 5). Means (±SEMs) are shown in all plots. All data are normalized to mean values in unexposed controls.