Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 25;9:15362. doi: 10.1038/s41598-019-51724-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

NT3 overexpression slightly increased noise-induced threshold shift in both DPOAEs (a) and ABRs (b), with a concomitant reduction in wave 1 amplitudes (c). GFP overexpression similarly increased noise-induced DPOAE thresholds shifts (d), while greatly increasing ABR thresholds (e) and reducing ABR wave 1 amplitudes (f) with or without noise exposure. Groups and group sizes were as follows: Controls (n = 15), Noise Only (n = 10), Vehicle then Noise (n = 5), Anc80-NT3₂₅₀ Only (n = 6), Anc80-NT3₂₅₀ then Noise (n = 7), Anc80-NT3₁₀₀₀ then Noise (n = 8) and Noise then Anc80-NT3₁₀₀₀ (n = 5). Group sizes for the GFP groups were as follows: Anc80-GFP₂₅₀ Only (n = 7), and Anc80-GFP₂₅₀ then Noise (n = 5). Wave 1 amplitude is extracted from each case at each frequency by averaging results from stimulus levels of 60, 70, and 80 dB SPL. Means (±SEMs) are shown in all plots. All data are normalized to mean values in unexposed controls.