Table 3.

Results of the association analysis of Streptococcus and knee joint effusion

Taxonomy	N	Model 1 CoE	Model 1 P-value	Model 2 CoE	Model 2 P-value
Class Bacilli	314	9.4  × 10−03	3.4 × 10−02	2.7 × 10−03	3.5 × 10−01
Order Lactobacillales	314	9.8 × 10−03	2.7 × 10−02	2.7 × 10−03	3.6 × 10−01
Family Streptococcaceae	310	9.6  × 10−03	1.7 × 10−02	3.0  × 10−03	2.6  × 10−01
Genus Streptococcus	308	1.0 × 10−02	1.3 × 10−02	3.3 × 10−03	2.1  × 10−01

Knee joint inflammation was measured as severity of effusion as measured on knee MRI. Knee MRI’s were only available for an all-female obese subgroup of the Rotterdam Study Microbiome dataset (n = 373). First model assessed the association of Knee effusion with the microbiome, adjusted for age, sex, DNA isolation batch and TimeInMail (technical covariates). Second model was WOMAC-pain score adjusted for age, sex, technical covariates and, effusion severity. P-values were determined by MaAsLin analysis. N = number of individuals in cohort where microbial abundancy is not zero for that taxonomy

CoE coefficient