Table 3.
Taxonomy | N | Model 1 CoE | Model 1 P-value | Model 2 CoE | Model 2 P-value |
---|---|---|---|---|---|
Class Bacilli | 314 | 9.4 × 10−03 | 3.4 × 10−02 | 2.7 × 10−03 | 3.5 × 10−01 |
Order Lactobacillales | 314 | 9.8 × 10−03 | 2.7 × 10−02 | 2.7 × 10−03 | 3.6 × 10−01 |
Family Streptococcaceae | 310 | 9.6 × 10−03 | 1.7 × 10−02 | 3.0 × 10−03 | 2.6 × 10−01 |
Genus Streptococcus | 308 | 1.0 × 10−02 | 1.3 × 10−02 | 3.3 × 10−03 | 2.1 × 10−01 |
Knee joint inflammation was measured as severity of effusion as measured on knee MRI. Knee MRI’s were only available for an all-female obese subgroup of the Rotterdam Study Microbiome dataset (n = 373). First model assessed the association of Knee effusion with the microbiome, adjusted for age, sex, DNA isolation batch and TimeInMail (technical covariates). Second model was WOMAC-pain score adjusted for age, sex, technical covariates and, effusion severity. P-values were determined by MaAsLin analysis. N = number of individuals in cohort where microbial abundancy is not zero for that taxonomy
CoE coefficient