Table 1.

Overview on main physico-chemical properties

Name	Core Material	Surface Modification	PPS	Surface Area (BET)	Agglomerate Size in F12K (z.average)	Zeta Potential
			[nm]	[m2/g]	[nm]	[mV]
SiO2_15_Unmod	Silica	None	15	200	42	−35.5
SiO2_15_Phospho		Phosphonate	15	200	93	− 42.3
SiO2_15_Amino		Amino	15	200	144	−30.9
SiO2_40		None	40	50	255	− 38.8
SiO2_7		None	8	300	275	−26.6
SiO2_7_TMS2		2% TMS	8	300	159	−1.0
SiO2_7_TMS3		3% TMS	8	300	403	−8.8
TiO2_NM105	Titanium dioxide	None	21	51	3490	−16.5
Graphene Oxide	Graphene oxide	None	–	–	1927	−16.2
Phthalocyanine Blue	Cu-phthalo-cyanine Halogenated Cu-phathalo-cyanine	None	17	53	1760	−24.1
Phthalocyanine Green		None	–	69	1784	−37.0
Mn2O3	Manganese oxide	None	50	19.9	676	−24.6

Main physico-chemical properties are: core material, surface coatings/other modifications, primary particle size (PPS) as given by the manufacturer, NM surface area as determined by BET and provided by the manufacturer, agglomerate sizes in serum containing F12K as determined by DLS and Zeta Potential at pH 7.4