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. 2019 Oct 9;116(43):21580–21591. doi: 10.1073/pnas.1911745116

Fig. 2.

Fig. 2.

Single depletion of CENP-T-W-S-X components induces centromere inactivation. (A) Cnp1 ChIP-seq reads mapped to centromeric regions of all 3 chromosomes in randomly chosen wip1∆, mhf1∆, and mhf2∆ strains (cen1inactive blue, cen2inactive pink, cen3inactive green) compared to wild-type strain (cen1/2/3active gray). (B) H3K9me2 ChIP-seq reads mapped to centromeric and pericentromeric regions of all 3 chromosomes in meiotic haploid progeny mhf2+ and heterozygous deletion diploid mhf2∆/+ (brown) compared to wild-type cells (gray). (C) Cnp1 ChIP-seq reads mapped to centromeric regions of all 3 chromosomes in 2 mhf2∆ meiotic haploid progeny from the same tetrad (cen2inactive pink, cen3inactive green). #1, Biological replicate 1. Diagrams, x axis and y axis, same as in Fig. 1.