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E. coli mutations that affect enterobactin siderophore utilization or import are synthetic lethal with C. elegans mitochondrial mutations. (A) spg-7(ad2249) animals grown on Δfes::kan E. coli arrest as L1 larvae. (Scale bar, 1,000 μm.) (B) Operon structure of genes in the enterobactin pathway. (C) Diagrammatic representation of enterobactin biosynthetic pathway in E. coli.
