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. 2019 Oct 8;116(43):21732–21738. doi: 10.1073/pnas.1907288116

Fig. 1.

Fig. 1.

Sustained ER stress induces hyperglycemia and hepatic gluconeogenesis. (A) Blood glucose levels in LD-Tun– or saline-treated (Con) C57BL/6 mice after 14 d. Results of glucose tolerance (B) and pyruvate tolerance (C) tests in the stressed and control mice are shown (n = 8 per group). (D) Relative mRNA expression levels of gluconeogenic genes in the liver of stressed and control mice. PEPCK, phosphoenolpyruvate carboxykinase. (E) Insulin tolerance test in mice receiving LD-Tun or saline. (F) Plasma insulin levels in the above groups. (G) Glucose production in MPHs treated with LD-Tun (0.25 μg/mL) or vehicle control (Con) for 48 h normalized to total protein levels. (H) Relative mRNA expression levels of gluconeogenic genes in the above groups. *P < 0.05, **P < 0.01, ***P < 0.001.