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. 2019 Oct 8;116(43):21732–21738. doi: 10.1073/pnas.1907288116

Fig. 2.

Fig. 2.

USP14 is required for the gluconeogenic effects of sustained ER stress. Relative expression of USP14 mRNA (A and C) and protein (B and D) in the liver of LD-Tun–treated and control (Con) mice (A and B) and cultured MPHs (C and D) is shown. (E and F) USP14 mRNA and protein levels in MPHs treated with LD-Tun + tauroursodeoxycholic acid (TUDCA), LD-Tun, or saline. (G and H) USP14 mRNA and protein levels in the liver of stressed and control mice treated with USP14 short hairpin RNA (shRNA) or negative control (n = 6 per group). Blood glucose levels (I) and glucose (J) and pyruvate (K) tolerance in the above groups are shown. n.s., not significant. (L) Relative mRNA levels of gluconeogenic genes in the liver of mice in the above groups. PEPCK, phosphoenolpyruvate carboxykinase. *P < 0.05, **P < 0.01, ***P < 0.001.