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. 2019 Oct 8;116(43):21732–21738. doi: 10.1073/pnas.1907288116

Fig. 4.

Fig. 4.

Hepatic USP14 knockdown improves glucose metabolism in obese mice. (A) Mice were fed a high-fat diet for 12 wk and then infected with adenoviral short hairpin RNA (shRNA) USP14 or negative control (Con). USP14 protein levels were determined by Western blots. (B) Blood glucose levels in the above groups on days 6 and 9 after infection. (C and D) Glucose and pyruvate tolerance in the above groups. (E) USP14 protein levels in ob/ob mice infected with adenoviral shRNA USP14 or Con shRNA. (F) Blood glucose levels in the above groups on days 6 and 9 after infection. (G and H) Glucose and pyruvate tolerance in the above groups (n = 6 per group). *P < 0.05, **P < 0.01, ***P < 0.001.