Table 1.

Sepsis Hospitalization Demographics

Characteristics	Non-cancer-related sepsis hospitalizations (N=869,722)	Cancer-related sepsis hospitalizations (N=234,641)	p
Patient Characteristics
Age (years), median (IQR)	69 (56–81)	71 (62–81)	<0.001
Charlson Comorbidity Index (revised)
median, IQR	3 (1–5)	0 (2–4)	<0.001
Pediatric Chronic Conditions (revised)
median, IQR	1 (0–2)	1 (1–2)	0.25
Gender
Male	436,000 (50.1%)	130,729 (55.7%)	<0.001
Hospitalization Characteristics
Organ dysfunction count
median (IQR)	1 (1–2)	1 (1–2)	0.63
Individual Organ Dysfunctions, N (%)
Renal	529,748 (60.9%)	137,481 (58.6%)	<0.001
Cardiovascular	396,849 (45.6%)	110,559 (47.1%)	<0.001
Pulmonary	338,155 (38.9%)	87,726 (37.4%)	<0.001
Hematologic	144,393 (16.6%)	47,136 (20.1%)	<0.001
Liver	54,872 (6.3%)	12,417 (5.3%)	<0.001
Neurologic	52,482 (6.0%)	10,624 (4.5%)	<0.001
None	44,478 (5.1%)	11,174 (4.8%)	<0.001
Site of Infection, N(%)			<0.001
Respiratory	328,419 (37.8%)	88,554 (37.7%)
Genitourinary	236,453 (27.2%)	56,550 (24.1%)
Gastrointestinal	86,216 (9.9%)	29,608 (12.6%)
Skin/soft tissue	66,894 (7.7%)	10,890 (4.6%)
Bacteremia/Fungemia	16,195 (1.9%)	6,425 (2.7%)
Joint/bone	17,305 (2.0%)	1,760 (0.8%)
Central Nervous System	6,750 (0.8%)	1,233 (0.5%)
Endocarditis/Myocarditis	1,965 (0.2%)	356 (0.2%)
Missing or Unknown	109,525 (12.6%)	39,265 (16.7%)
Hospital Length of Stay (days), Alive
median (IQR)	8 (4–14)	8 (4–14)	<0.001
Hospital Length of Stay (days), Deceased
median (IQR)	6 (2–14)	6 (2–14)	<0.001
In-Hospital Mortality	169,791 (19.5%)	65,419 (27.9%)	<0.001

Definitions of site of infection and acute organ dysfunctions are presented in Supplemental Table 1.

Payer Type demographics are presented in Supplemental Table 6.

IQR, interquartile range; SD, standard deviation