Figure 1. Cerebellar outflow pathway lesion load.

The cerebellar outflow pathway is shown in blue on the left extending from the deep cerebellar nuclei along the superior cerebellar peduncles. The entire region of interest was separated into 1-mm oblique coronal slices perpendicular to the angle of the superior cerebellar peduncles (17°), of which 3 examples are shown. A sample lesion is shown in red that overlaps with the cerebellar outflow pathway. The extent the lesion overlap with the outflow pathway is quantified as a proportion of total voxels for each slice. Slice 83 (1) has a damaged proportion value of 0.15; slice 77 (2) has a damaged proportion of 0.73; and slice 71 (3) has a proportion of damage of 0.30. Across all slices, the maximum proportional value served as the cerebellar outflow pathway lesion load, which was used for subsequent analyses. This value would come from slice 77 (2) in the right panel among the slices shown, where the lesion overlaps with 73% of voxels in the outflow pathway for that slice.