Figure 5. Lesion-associated networks derived from adult data.

(A) Network of regions functionally connected to the cerebellar region associated with cerebellar cognitive affective syndrome (CCAS) is shown. This network was derived from seed-based functional connectivity from a large normative dataset of healthy adults using the result shown in figure 4B as the seed region. Regions with positively correlated oscillatory patterns are shown in warm colors, and negatively correlated networks did not reach significance at this threshold. Peak coordinates for the parvocellular division of the mediodorsal nucleus of the thalamus, left temporal stem, right temporal stem, and right red nucleus are as follows: (−1, −10, 10), (−25, −20, −6), (29, −21,-4), and (5, −24, −9), respectively. (B) Fisher r-to-z transformed scores show significantly higher functional connectivity between lesion sites causing CCAS compared to those not associated with CCAS at the mediodorsal (MD) nucleus of the thalamus (parvocellular), right temporal stem, and right red nucleus with values of p = 0.0029, 0.0012, and 0.0080, respectively. Other sites of the network had higher correlation with CCAS lesions but did not reach statistical significance after correction for multiple compressions (left temporal stem and anterior cingulate cortex with p = 0.0180 and 0.1790, respectively). Error bars represent SEM.