Table 1.

Characteristics of the main transcription factors (TFs) promoting the earlier stages of MSC differentiation. In italics, the TFs found to be involved in the mechanotranscription mechanism are highlighted

Differentiation pathways	Factors	Type	Molecular weight (kDa)	Ref.
Osteogenesis	Runx2 (Cbfa1)	Runt-related TF	18.8	Yanagisawa et al. 2007 Yang et al. 2014 Murphy et al. 2012 Hime and Abud 2013
	Osterix	Zinc Finger TF	44.9	Yanagisawa et al. 2007 Hime and Abud 2013
	Dlx Family	Homeobox TF	Dlx3 = 31.7 Dlx5 = 31.5 Dlx6 = 32.5	Yanagisawa et al. 2007 Hime and Abud 2013
Adipogenesis	PPARγ	Nuclear Receptor	54.7	Yanagisawa et al. 2007 Yang et al. 2014 Li et al. 2015 Case et al. 2013 Hime and Abud 2013
	C/EBPS	Basic Leucine Zipper Domain TF	α = 35.9 β = 36.1 γ = 28.4	Li et al. 2015 Hime and Abud 2013
	SREBP1/ADD1	Sterol regulatory element-binding TF	~ 49	Hime and Abud 2013
Chondrogenesis	Sox9	SRY-related High mobility group-box TF	56.1	Yanagisawa et al. 2007 Murphy et al. 2012 Hime and Abud 2013
	Sox5		84	Yanagisawa et al. 2007 Hime and Abud 2013
	Sox6		91.9	Yanagisawa et al. 2007 Hime and Abud 2013
	Runx2 (Cbfa-1)	Runt-related TF	18.8	Yanagisawa et al. 2007 Yang et al. 2014 Murphy et al. 2012 Hime and Abud 2013
Myogenesis	Myod	Basic helix loop helix TF	34.5	Yanagisawa et al. 2007 Pownall et al. 2002
	Myogenin		25	Pownall et al. 2002
	Myf5		28.3	Pownall et al. 2002
	Myf6 (MRF4)		26.9	Pownall et al. 2002
Tenogenesis	Scleraxis	Basic helix loop helix TF	21.6	Wang et al. 2018
	Mohawk	Homeobox TF	39.4	Liu et al. 2015
	Egr1	C2H2-type zinc finger TF	57.5	Guerquin et al. 2013
Neurogenesis	Ascl1	Basic helix loop helix TF	25.5	Araújo et al. 2018
	Neurogenin		25.7	Araújo et al. 2018 Schäck et al. 2016
	Foxa2	Forkhead box transcription protein	48.9	Marrelli et al. 2015