Fig. 3.

a Western blot analysis showed increased hippocampal 5-HT_1AR protein levels in resilient animals; *p < 0.05 vs. control and ##p < 0.01 vs. resilient group of rats (n = 8/group). The left lower panel represents results from an in situ hybridization study of the expression level of mRNA encoding 5-HT_1AR in b CA1, c CA2, d CA3, and e dentate gyrus (DG) subregions of the dHIP (n = 5–10/group). The right lower panel represents the results from [³H]8-OH-DPAT agonist binding to 5-HT_1AR in f CA1, g CA2, h CA3, and i DG subregions of the hippocampus. Resilient animals exhibited increased [³H]8-OH-DPAT binding to 5-HT_1AR in f CA1, g CA2, and h CA3 subregions of the dHIP compared to non-stressed and anhedonic littermates (n = 6–7/group),**p < 0.01, ***p < 0.001 vs. control; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. anhedonic