Table 2.

Mean ± standard error of the diameter of oocyte nucleus, oocyte, and follicle and number of granulosa cells from primordial, transition, and primary follicles from the control, rapamycin, and caloric restriction (CR) groups

	Control	Rapamycin	CR	P
Primordial
Nucleus1	3.2 ± 0.1a	3.1 ± 0.2a	3.8 ± 0.2b	0.0054*
Oocyte1	5.9 ± 0.4ab	5.4 ± 0.4a	7.0 ± 0.4b	0.0228*
Follicle1	10.8 ± 0.6a	9.8 ± 0.7a	11.7 ± 0.5a	0.0787
Granulosa2	4.1 ± 0.2a	4.2 ± 0.2a	4.4 ± 0.2a	0.5516
Transition
Nucleus1	3.9 ± 0.1a	3.7 ± 0.1a	4.1 ± 0.2a	0.1871
Oocyte1	7.9 ± 0.3a	7.0 ± 0.3a	7.5 ± 0.2a	0.1088
Follicle1	15.7 ± 0.5a	13.3 ± 0.6b	14.0 ± 0.3ab	0.0053*
Granulosa2	7.0 ± 0.3a	6.3 ± 0.3a	6.4 ± 0.2a	0.1572
Primary
Nucleus1	5.7 ± 0.2a	5.1 ± 0.2a	5.4 ± 0.3a	0.2062
Oocyte1	17.0 ± 1.8a	15.3 ± 1.1ab	11.5 ± 0.8b	0.0094*
Follicle1	29.8 ± 2.6a	27.2 ± 1.9ab	21.7 ± 1.3b	0.0159*
Granulosa2	15.7 ± 1.5ab	17.6 ± 1.2a	11.8 ± 0.8b	0.0027*

Different letters represent statistical difference in the row

*Statistical difference at P < 0.05

¹Measured in micrometers

²Number of granulosa cells